Phosphorylation is a post translational modification (PTM) of proteins and lipids and it represents one of the most efficient ways to regulate protein and lipid function in cells. Protein kinases are one of the largest classes of enzymes and they are responsible for phosphorylating proteins. Kinases themselves are turned on or off by growth factors, cytokines and hormones to regulate a diverse set of downstream cell signaling pathways.
Defective cell signaling is implicated in several inherited disorders and diseases, such as cancer, diabetes, and cardiovascular disease. Mutations in kinases can lead to defective signaling and indeed, there are many characterized kinase mutants that play a causal role in disease. Moreover, cancers can acquire drug-resistance mutations such as in the case of EGFR (T790M), which can diminish the efficacy of conventional and targeted therapies.
SignalChem strives to provide researchers with the right tools for their drug discovery efforts and these include disease-related kinase mutants. They are leading the way by providing one of the largest libraries of Active Kinase Mutant enzymes in the industry. They are continually developing new clinically relevant kinase mutants.
For a list of all kinase from SignalChem check out the following link.
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