Stratech Scientific now supply, SynVivo (CFD Research Corporation) products.
SynVivo products are a physiological, cell-based microchip platform that provides a morphologically and biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery.
SynVivo’s patented technology for recreating microvasculature scale, shape, fluidics, and cellular constructs provides the most realistic in vitro testing platform for drug discovery, delivery, efficacy, and toxicity assays.
Static well plate and linear flow channel assays cannot differentiate between shapes of drug delivery vehicles, whereas SynVivo can. As particle shape becomes a more relevant area of study for drug delivery, SynVivo can provide new insights that can help optimize drug delivery.
SynVivo can be used to capture real-time distribution of drugs in the microvasculature. Stagnant and recirculation zones that affect overall drug delivery and distribution can be readily identified.SynVivo can be used to quantify drug particle distribution patterns through analysis of shear rate and adhesion.
In addtion, SynVivo can support the growth of endothelial cells, cancer cells and many other cell types for mimicking healthy and disease conditions. In addition, targeted drug delivery can be quantified and optimized using the in vivo morphology and fluidic conditions in SynVivo.
For further information on available products visit our product listing.
Below is a video illustrating how the system works.
Cellular behavior and microcirculatory dysfunction:
SynVivo chips can be used to study real-time cell-cell interactions for:
- Inflammation (leukocyte-endothelium),
- Cancer (tumor-endothelium),
- Thrombosis (platelet-endothelium), and
- Infection (microbial-endothelium)
under physiological fluid flow conditions representing healthy and pathological conditions.
|Leukocytes rolling and adhering on endothelial cells||Infection of brain neuronal cells||Infection on neuronal cells|
Where can I find more information about SynVivo?
Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.